Here's the list of the largest lottery prizes in U.S. history — and the people who won them. $1.586 billion Powerball. Date: January 2016. $1.537 billion Mega Millions. $768.4 million Powerball. $758.7 million Powerball. $656 million Mega Millions. $648 million Mega Millions. $590.5 million Powerball. $587.5 million Powerball.